Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
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Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
Normal brain function requires that the overall synaptic activity in neural circuits be kept constant. Long-term alterations of neural activity lead to homeostatic regulation of synaptic strength by a process known as synaptic scaling. The molecular mechanisms underlying synaptic scaling are largely unknown. Here, we report that all-trans retinoic acid (RA), a well-known developmental morphogen...
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ژورنال
عنوان ژورنال: Neuron
سال: 2008
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2008.08.012